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KMID : 0356920080540050507
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Korean Journal of Anesthesiology
2008 Volume.54 No. 5 p.507 ~ p.512
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Hemodynamic Responses of Pretreatments Designed to Reduce Withdrawal Movements Following Rocuronium Injection: A Comparison of Alfentanil with Lidocaine
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Park Soon-Eun
Park Se-Hun
Cho Young-Woo
Son Hee-Won
Lee Ji-Ho
Kim Dae-Young
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Abstract
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Background: This study was conducted to compare the efficacy of intravenous alfentanil and lidocaine as a pretreatment for the prevention of withdrawal movements following a rocuronium injection and hemodynamic change following tracheal intubation.
Methods: This study evaluated 180 patients that were divided into the following 3 pretreatment groups: group C: normal saline, group L: lidocaine 1 mg/kg, group A: alfentanil 10?g/kg. Anesthesia was induced using 5 mg/kg thiopental sodium, after which the test drug was injected. Rocuronium (1 mg/kg) was then administered 1 minute after the test drug was injected over 5 seconds and the response was characterized as one of the following: no movement, movement limited to the wrist, to the elbow or to the shoulder. Intubation was performed 1 minute later. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were then recorded at each of the following points: T1: preinduction, T2: immediately prior to rocuronium injection, T3: immediately after rocuronium injection, T4: immediately prior to intubation, T5: immediately after intubation, T6: 1 minute after intubation, T7: 5 minutes after intubation.
Results: The incidence of withdrawal movement was significantly lower in group A than groups C and L (P ＜ 0.05). In addition, SBP, DBP and HR following intubation were significantly lower in group A than group C and group L (P ＜ 0.05).
Conclusions: Pretreatment with 10?g/kg of alfentanil effectively reduced the incidence of withdrawal movement in response of rocuronium injection and caused minimal hemodynamic changes following intubation.
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KEYWORD
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alfentanil, hemodynamic change, lidocaine, rocuronium, withdrawal movement
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